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KMID : 0604620060130020033
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Dongguk Journal of Medicine
2006 Volume.13 No. 2 p.33 ~ p.42
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Differential Regulation of Neural Stem Cells in Normal Rat Brain After Chronic Lithium Treatment
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Park June-Hyuk
Jung Yong-Wook
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Abstract
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Lithium has long been a primary drug used to treat bipolar mood disorder. Recently, in vivo and in vitro studies have demonstrated neuroproliferative actions of lithium, even though the drug’s therapeutic mechanisms remain obscure. The present study was undertaken to examine the possibility whether chronic treatment with lithium in normal rats can induce neuroproliferation in subventricular zone (SVZ) of lateral ventricle (LV) and/or subgranular zone (SGZ) of dentate gyrus (DG). Chronic lithium treatment was produced by pellet of standard diet containing 40 mM/dl and/or 60 mM/dl lithium citrate for 25 days. The serum concentrations of Li^(+) were increased to 0.40±0.08 mEq/L in the 40 mM/dl lithium treated rats and 60±0.1 mEq/L in the 40 mM/dl plus 60 mM/dl lithium treated rats which is therapeutic dose of clinical practice. The numbers of BrdU?positive cells were determined using immunohistochemistry after chronic lithium treatment. There was a significant increase of BrdU-positive cells in the SGZ of the DG after therapeutic dose of lithium treatment. Selective enhancement of the proliferation in neural progenitors in subgranular zone (SGZ) of the dentate gyrus (DG) in normal adult rat hippocampus strongly suggest the possibility that chronic lithium treatment may have therapeutic potential for stroke via neuroproliferation.
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KEYWORD
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lithium, dentate gyrus, neuroproliferation
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